Early Effects of Glucocorticoid Treatment on Amino Acid Metabolism in Lymphosarcoma P1798l
نویسندگان
چکیده
Administration of 9a-fluoroprednisolone causes an early (3 hr) decrease of basic amino acid incorporation into CS-P1798 lymphosarcoma protein. Decreased utilization of neutral amino acids is observed after 6 hr. These effects are accompanied by expansion of the intratumoral free amino acid pool in CS-but not in CR-P1798. Thus, decreased incorporation of radioactive amino acids in CS-P1798 appears to result from pool dilution of the tracers. It is suggested that the increase in intratumoral levels of free amino acids is a consequence of steroid-induced breakdown of tumor protein and that this effect may be related to tumor regression.
منابع مشابه
Early effects of glucocorticoid treatment on amino acid metabolism in lymphosarcoma P1798.
Administration of 9a-fluoroprednisolone causes an early (3 hr) decrease of basic amino acid incorporation into CS-P1798 lymphosarcoma protein. Decreased utilization of neutral amino acids is observed after 6 hr. These effects are accompanied by expansion of the intratumoral free amino acid pool in CS-but not in CR-P1798. Thus, decreased incorporation of radioactive amino acids in CS-P1798 appea...
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